Hmm I wonder if anyone's done this backwards? As in a asexual having to deal with sexual issues. An a-parent having to deal with a sexual offspring is something I've never seen explored, from either side actually... (hmm that does twiddle the muse a bit, I'll see if I can push that idea attached to it into a full fledged fiction... if I can get it off the ground would you like a link?) Or a sexual character coming to terms to an asexual (not just making a comment about it for comedy's sake, but actually understanding and accepting the person as they are)

Save for Misty's work (which you've already mentioned) and an antagonistic character in CS friedman's work (he pushes the definition a bit but he's a nasty deconstruction of the whole seductive vampire thing in a very grim dark setting)I honestly can't think of any asexual and sexual's interaction and the issue being broached in a matter that was handled both tactfully and not for laughs.

A shame really since there's so much potential with the idea, even if it is issueficy.